Chronic migraines can disrupt work, family, and daily life. For patients across Chapel Hill and the Triangle, Ketamine Wellness Institute offers IV ketamine therapy as a treatment option when standard medications and lifestyle changes have not been enough. Since 2017, our clinic has provided physician-supervised ketamine care in a safe, private environment. Each infusion is overseen by a physician anesthesiologist, ensuring patient safety and individualized dosing.
Ketamine works by influencing NMDA receptors and glutamate, which play a role in pain signaling. By interrupting overactive pain pathways in the brain and spinal cord, ketamine may reduce the severity and frequency of migraine attacks. Patients who have tried numerous medications without success sometimes experience improvement after beginning ketamine therapy. While not every patient responds the same way, studies suggest ketamine can be a valuable option for those with refractory migraines.
Treatment begins with an initial consultation where your medical history, migraine pattern, and past treatments are reviewed. If IV ketamine is appropriate, most patients start with a stabilization series of six infusions spread over two to three weeks. For migraine treatment, infusions may last longer than those for mood disorders—up to two to three hours per session.
During the infusion, you will be in a private room with dimmable lighting and a comfortable recliner. A nurse places a small IV line, and your vital signs are monitored throughout. Some patients choose to bring headphones or a blanket to help them relax. After the infusion, you remain on site for recovery before being discharged with your driver.
Patients considered for IV ketamine typically have chronic migraines that have not improved with preventive medications, triptans, or other therapies. Suitability is based on your overall health, current medications, and safety profile. Our physicians conduct a thorough review before recommending treatment.
Patients who respond often notice a reduction in attack frequency or intensity, which can help improve quality of life and restore the ability to participate in work, school, and family activities.
IV ketamine for migraines is considered an off-label treatment and is typically not covered by insurance. Our staff will review pricing in detail during your consultation and explain available payment options so you can make an informed decision about moving forward.
Our clinic is conveniently located at 5915 Farrington Rd, Suite 105 in Chapel Hill, NC. Patients come to us from Chapel Hill, Durham, Raleigh, and other parts of the Triangle for care they can trust.
Conditions Treated
5915 Farrington Rd Suite 105
Chapel Hill, NC 27517