Ketamine Wellness Institute in Chapel Hill offers two distinct approaches to ketamine treatment: IV ketamine infusions and SPRAVATO® nasal spray. Both are evidence-based, physician-supervised options designed for patients who need more than standard therapies. The choice between them depends on diagnosis, goals, and coordination with your care team.
IV ketamine therapy is delivered through an infusion in a private clinic setting. At Ketamine Wellness Institute of Chapel Hill, every infusion is overseen by physician anesthesiologists with extensive experience in ketamine administration.
IV ketamine is used for a wide range of conditions, including treatment-resistant depression, anxiety, PTSD, OCD, migraines, neuropathic pain, and chronic pain. Dosing is individualized, and response is carefully tracked to refine the plan.
SPRAVATO® is an FDA-approved nasal spray for adults with treatment-resistant depression and for short-term use in major depressive disorder with suicidal thoughts or behaviors. It is only available in REMS-certified clinics, which ensures safe administration and monitoring.
At Ketamine Wellness Institute of Chapel Hill, patients receive SPRAVATO® under direct observation with a two-hour recovery period after each session. The treatment follows a structured dosing schedule and may be eligible for insurance coverage.
Administration: IV infusion vs. intranasal spray.
Indications: IV ketamine is used across mood and pain conditions; SPRAVATO® is FDA-approved for specific depression diagnoses.
Oversight: Both are supervised by physicians; SPRAVATO® also requires a REMS-certified setting and observation period.
Coverage: IV ketamine is usually self-pay; SPRAVATO® may be insurance-covered.
Both treatments are safe, closely monitored, and offered in our Chapel Hill clinic.
Neither approach is inherently better—what matters is which one aligns with your diagnosis, treatment history, and goals. Some patients respond best to IV ketamine, others to SPRAVATO®, and some may consider a combination with psychotherapy or medication management.
Our team will review your history, explain both paths, and design a plan that fits your needs.